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Ethanol → N-[2-[(2R)-1-aminopropan-2-yl]-6-methyl-1-oxoisoquinolin-5-yl]-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide

HRID 418536

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HRID 418536 반응식

[N:1]([CH2:4][C@H:5]([N:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH3:32])[C:13]=2[NH:17][C:18](=[O:31])[CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[C:22]([F:30])[CH:21]=2)[C:8]1=[O:33])[CH3:6])=[N+]=[N-].C(O)C.[Cl-].[NH4+].O>[Fe]>[NH2:1][CH2:4][C@H:5]([N:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH3:32])[C:13]=2[NH:17][C:18](=[O:31])[CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:28])([F:29])[F:27])=[C:22]([F:30])[CH:21]=2)[C:8]1=[O:33])[CH3:6]

참가 물질 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

6

반응물 4

HCID 702Ethanol

HCID 25517Ammonium Chloride

HCID 59845723(R)-N-(2-(1-azidopropan-2-yl)-6-methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide

생성물 1

HCID 25014313N-[2-[(2R)-1-aminopropan-2-yl]-6-methyl-1-oxoisoquinolin-5-yl]-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide수율 53.3%

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

A solution of (R)—N-(2-(1-azidopropan-2-yl)-6-methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide (0.6 g, 0.001 mol) in ethanol (50 mL, 0.8 mol) was heated at 85° C. A solution of ammonium chloride (0.6 g, 0.01 mol) in water (15 mL, 0.83 mol) was added followed by iron powder (0.6 g, 0.01 mol). The mixture was stirred at the same temperature for 3 hours and poured onto dichloromethane (200 mL) and extracted. The residue was purified by reverse phase HPLC to afford the desired product as a white solid (232 mg, yield 50%).

후처리

additionpoured onto dichloromethane (200 mL)
extractionextracted
customThe residue was purified by reverse phase HPLC

출처 및 근거

ORD 기록: ord-fd821094142f4ced8bc1ca00cef29173
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08093265B2

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