N-(2-Methoxy-phenyl)-malonamic acid → n1-(3-Fluoro-4-(2-(1-methyl-1h-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-n3-(2-fluoroxyphenyl)malonamide

반응식

[F:1]C1C=C(N)C=CC=1OC1C=CN=C2C=C(C3N(C)C=CN=3)SC=12.[F:25][C:26]1[CH:27]=[C:28]([NH:48][C:49](=[O:62])[CH2:50][C:51]([NH:53][C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][C:55]=2[O:60]C)=[O:52])[CH:29]=[CH:30][C:31]=1[O:32][C:33]1[CH:38]=[CH:37][N:36]=[C:35]2[CH:39]=[C:40]([C:42]3[N:43]([CH3:47])[CH:44]=[CH:45][N:46]=3)[S:41][C:34]=12.COC1C=CC=CC=1NC(=O)CC(O)=O.FC1C=CC=CC=1NC(=O)CC(O)=O>>[F:25][C:26]1[CH:27]=[C:28]([NH:48][C:49](=[O:62])[CH2:50][C:51]([NH:53][C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][C:55]=2[O:60][F:1])=[O:52])[CH:29]=[CH:30][C:31]=1[O:32][C:33]1[CH:38]=[CH:37][N:36]=[C:35]2[CH:39]=[C:40]([C:42]3[N:43]([CH3:47])[CH:44]=[CH:45][N:46]=3)[S:41][C:34]=12