Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
7-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran → 4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 7-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran | HCID 57775518 | — |
| 반응물 | 1-Phenyl-1H-indazol-4-amine hydrochloride | HCID 66648452 | — |
| 생성물 | 4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol | HCID 57615941 | — |
반응 단계
Prepared similarly to Example 7 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and 1-phenyl-1H-indazol-4-amine hydrochloride (as the free base, Intermediate 8).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093281B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-ebb741a2df6a40c8b44af8efc4c37919 |
| 출처 메모 | uspto-grants-2012_01 |