Tetrahydrofuran → HCID 57912422, 화합물

HRID 418870노트

반응식

HRID 418870 반응식
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:16][C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[O:13][CH:12]=2)=[CH:7][CH:6]=1)(=O)C.C1COCC1.C([O-])([O-])=O.[K+].[K+]>CO>[O:16]1[C:11]([C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=2)=[CH:12][O:13][C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]1=2

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 11430Potassium CarbonateHCID 57912410HCID 57912410, 화합물

생성물 1

HCID 57912422HCID 57912422, 화합물수율 77.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-(benzo[b][1,4]dioxin-2-yl)phenyl acetate (270 mg, 1.0 mmol) in MeOH:THF (5 mL: 3 mL) and K2CO3 (167 mg, 1.2 mmol) was stirred for 30 min at rt. The solvent was removed under reduced pressure and water was added. The solution was neutralized by dilute HCl and the solid was isolated by filtration, washed well with water and dried to give 175 mg of 4-(benzo[b][1,4]dioxin-2-yl)phenol (77%). MS (ES) m/z: 225.97 (M), 224.93 (M−1); Mp. 137-140° C.

후처리

  1. customThe solvent was removed under reduced pressure and water
  2. additionwas added
  3. customthe solid was isolated by filtration
  4. washwashed well with water
  5. customdried

출처 및 근거

ORD 기록
ord-3b096b12d41b46a097f66f621040daa8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093273B2

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