4-Fluorophenol → 5-Chloro-2-(4-fluoro-phenoxy)-3-nitro-pyridine

HRID 418980

반응식

HRID 418980 반응식
Br[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([Cl:11])=[CH:4][N:3]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:11][C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([O:19][C:16]2[CH:17]=[CH:18][C:13]([F:12])=[CH:14][CH:15]=2)=[N:3][CH:4]=1

참가 물질

5

반응물 3

HCID 97324-FluorophenolHCID 11430Potassium CarbonateHCID 2806812-Bromo-5-chloro-3-nitropyridine

생성물 1

HCID 579424105-Chloro-2-(4-fluoro-phenoxy)-3-nitro-pyridine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared according to general procedure A using 2-bromo-5-chloro-3-nitro-pyridine (750 mg, 3.17 mmol), 4-fluorophenol (463 mmol, 4.13 mmol), K2CO3 (437 mg, 4.75 mmol) and DMF (5 mL). MS m/z: 269.0 (M+H).

출처 및 근거

ORD 기록
ord-92c9741dc15d4b47975d57f78a59eddd
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093247B2

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