Acetophenone → (E)-N-[(4-nitrophenyl)methoxy]-1-phenylethanimine

HRID 41927

반응식

HRID 41927 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].Cl.[N+:11]([C:14]1[CH:22]=[CH:21][C:17]([CH2:18][O:19][NH2:20])=[CH:16][CH:15]=1)([O-:13])=[O:12]>>[N+:11]([C:14]1[CH:15]=[CH:16][C:17]([CH2:18][O:19]/[N:20]=[C:1](/[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)\[CH3:2])=[CH:21][CH:22]=1)([O-:13])=[O:12]

참가 물질

3

반응물 2

HCID 7410AcetophenoneHCID 74967Hydroxylamine, O-((4-nitrophenyl)methyl)-, hydrochloride (1:1)

생성물 1

HCID 25100092(E)-N-[(4-nitrophenyl)methoxy]-1-phenylethanimine수율 77%

실험 절차

Acetophenone (20) (150 mg, 1.25 mmol) was condensed with compound 19 (280 mg, 1.37 mmol) according to the general procedure II-A defined above. After heating the reaction mixture for 2 h it was cooled and the solvent removed under reduced pressure. The resulting solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30252 (258 mg, 77%) as a pale-yellow solid, m.p. 91.3-92.3° C.

후처리

  1. temperatureAfter heating the reaction mixture for 2 h it
  2. temperaturewas cooled
  3. customthe solvent removed under reduced pressure
  4. filtrationThe resulting solid was filtered off
  5. washwashed with cold isopropanol (3.0 mL)

출처 및 근거

ORD 기록
ord-23a916c9fb6443c8ab25be0c5e823b60
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536157B2

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