1-(3-Hydroxy-4-methoxyphenyl)ethanone → 4-[[(E)-1-(3-hydroxy-4-methoxyphenyl)ethylideneamino]oxymethyl]benzonitrile

HRID 41939

반응식

HRID 41939 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:10](=O)[CH3:11])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].Cl.[C:14]([C:16]1[CH:24]=[CH:23][C:19]([CH2:20][O:21][NH2:22])=[CH:18][CH:17]=1)#[N:15]>>[C:14]([C:16]1[CH:24]=[CH:23][C:19]([CH2:20][O:21]/[N:22]=[C:10](/[C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([OH:1])[CH:3]=2)\[CH3:11])=[CH:18][CH:17]=1)#[N:15]

참가 물질

3

반응물 2

HCID 956931-(3-Hydroxy-4-methoxyphenyl)ethanoneHCID 19692695113211-35-1

생성물 1

HCID 251004114-[[(E)-1-(3-hydroxy-4-methoxyphenyl)ethylideneamino]oxymethyl]benzonitrile수율 51%

실험 절차

Acetophenone 12 (30 mg, 0.181 mmol) was condensed with O-(4-cyanobenzyl)hydroxylamine hydrochloride (35) (37 mg, 0.200 mmol) according to the general procedure II-B defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The ensuing solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30283 (27 mg, 51%) as a white solid, m.p. 125.9-129.7° C.

후처리

  1. temperatureAfter being heated for 3 h the reaction mixture
  2. temperaturewas cooled
  3. customthe solvent removed under reduced pressure
  4. filtrationThe ensuing solid was filtered off
  5. washwashed with cold isopropanol (3.0 mL)

출처 및 근거

ORD 기록
ord-046a4e99e2c84c21b7473af2469c6e6d
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536157B2

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