참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | 5-Fluoro-2-nitrophenol | HCID 9937 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Ethoxy-4-fluoronitrobenzene | HCID 12918153 | 99.1% |
반응 단계
To 5-fluoro-2-nitrophenol (8.3 g, 52.83 mmol) in 50 mL of DMF was added K2CO3 (14.6 g, 105.7 mmol), and ethyl iodide (8.53 mL, 105.7 mmol). The mixture was stirred at 60° C. for 24 h in a sealed tube. The mixture was poured into 500 mL of H2O and extracted with diethyl ether, dried (Na2SO4), filtered, and rotovaped down to give the title compound of step A (9.69 g, 52.33 mmol, 99%). 1H NMR (400 MHz, CDCl3) δ ppm 7.88-7.94 (m, 1H), 6.71-6.77 (m, 1H), 6.66-6.71 (m, 1H), 4.11-4.19 (m, 2H), 1.45-1.51 (m, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08093239B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-47097988c57843c7be2f334c5da30d7c |
|---|
| 출처 메모 | uspto-grants-2012_01 |
|---|
