Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → (3E)-6-methoxy-3-[(4-nitrophenyl)methoxyimino]-1,2-dihydroinden-5-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one | HCID 233148 | — |
| 반응물 | (4-Nitrobenzyl)hydroxylamine hydrochloride | HCID 86662371 | — |
| 반응물 | (E)-6,7-dimethoxy-N-[(4-nitrophenyl)methoxy]-3,4-dihydro-2H-naphthalen-1-imine | HCID 87138450 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (3E)-6-methoxy-3-[(4-nitrophenyl)methoxyimino]-1,2-dihydroinden-5-ol | HCID 87138616 | 48% |
반응 단계
6-Hydroxy-5-methoxy-1-indanone (114 mg, 0.64 mmol) was subjected to reaction with (4-nitrobenzyl)hydroxylamine hydrochloride (149 mg, 0.73 mmol) in ethanol (5 mL) and pyridine (0.6 mL, 7.74 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime. The solid obtained on work up was recrystallized (isopropanol) to yield the title compound (101 mg, 48%) as off-white crystals, m.p. 146-149° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536157B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-07df91bd6c934ce29726f4ddea1a72e3 |
| 출처 메모 | uspto-grants-2013_09 |