Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → (E)-N-(2,1,3-benzoxadiazol-5-ylmethoxy)-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-imine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 3,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone | HCID 266816 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 반응물 | (E)-6,7-dimethoxy-N-[(4-nitrophenyl)methoxy]-3,4-dihydro-2H-naphthalen-1-imine | HCID 87138450 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (E)-N-(2,1,3-benzoxadiazol-5-ylmethoxy)-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-imine | HCID 87138747 | 88% |
반응 단계
6,7-Dimethoxy-1-tetralone (40 mg, 0.19 mmol) was subjected to reaction with 0-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)hydroxylamine hydrochloride (41 mg, 0.20 mmol) in ethanol (2 mL) and pyridine (0.2 mL, 2.58 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime. Subjection of the material obtained on work up to flash chromatography (3:7 v/v ethyl acetate/hexane elution) afforded the title compound as white crystals (60 mg, 88%), m.p. 139-140° C., Rf 0.4.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536157B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-fc6cca299ab34329b5ce188c59f8f9ed |
| 출처 메모 | uspto-grants-2013_09 |