Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → (E)-N-(2,1,3-benzoxadiazol-5-ylmethoxy)-5,6-dimethoxy-2,3-dihydroinden-1-imine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 5,6-Dimethoxy-1-indanone | HCID 75018 | — |
| 반응물 | O-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)hydroxylamine hydrochloride | HCID 66760966 | — |
| 반응물 | (E)-6,7-dimethoxy-N-[(4-nitrophenyl)methoxy]-3,4-dihydro-2H-naphthalen-1-imine | HCID 87138450 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | (E)-N-(2,1,3-benzoxadiazol-5-ylmethoxy)-5,6-dimethoxy-2,3-dihydroinden-1-imine | HCID 87138642 | 85.3% |
반응 단계
5,6-Dimethoxy-1-indanone (38 mg, 0.19 mmol) was subjected to reaction with O-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)hydroxylamine hydrochloride (39 mg, 0.19 mmol) in ethanol (2 mL) and pyridine (0.2 mL, 2.58 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime. Subjection of the material obtained on work up to flash chromatography (3:7 v/v ethyl acetate/hexane elution) afforded the title compound as off-white crystals (55 mg, 82%), m.p. 163-166° C., Rf 0.4.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536157B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-79490ee6dbb0457fbbbf3dc97b5fd167 |
| 출처 메모 | uspto-grants-2013_09 |