2-Chloro-5-nitro-3-(trifluoromethyl)pyridine → 6-Chloro-5-(trifluoromethyl)pyridin-3-amine

HRID 41976노트

반응식

HRID 41976 반응식
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N+:12]([O-])=O)=[CH:4][N:3]=1>C(OCC)(=O)C.[Zn+2].[Br-].[Br-]>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([NH2:12])=[CH:6][C:7]=1[C:8]([F:11])([F:9])[F:10]

참가 물질

4

반응물 1

HCID 38491402-Chloro-5-nitro-3-(trifluoromethyl)pyridine

생성물 1

HCID 135322446-Chloro-5-(trifluoromethyl)pyridin-3-amine수율 92.1%

시약·촉매·용매 2

HCID 10421208Zinc bromide촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 2-chloro-5-nitro-3-(trifluoromethyl)pyridine (5.25 mmol, 1.19 g), ZnBr2 (1.05 mmol, 0.200 g) and 5% Pt (C) (1.58 mmol, 0.31 g) in ethyl acetate (50 ml) was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off and the solid was washed with warmed ethanol. The solvent was evaporated affording the expected product (0.95 g, yield 92%).

후처리

  1. filtrationThe catalyst was filtered off
  2. washthe solid was washed with warmed ethanol
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-dd5d5aedb746487fad31455fd2cacb7e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536165B2

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