Oxalyl chloride → (S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate

HRID 419769노트

반응식

HRID 419769 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@@:12]1([CH3:19])[C:16](O)=[O:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:23])=O>ClCCl.CN(C)C=O>[Cl:23][C:16]([C@:12]1([CH3:19])[CH2:13][CH2:14][CH2:15][N:11]1[C:9]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10])=[O:17]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 18604408HCID 18604408, 화합물

생성물 1

HCID 86643491(S)-benzyl 2-(chlorocarbonyl)-2-methylpyrrolidine-1-carboxylate

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

A solution of (S)-1-(benzyloxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid (1.50 g) in dichloromethane (30 mL) was treated with oxalyl chloride (0.65 mL) and 3 drops of N,N-dimethylformamide at ambient temperature for 1.5 hours. The mixture was concentrated and the crude material used in the next step without further purification.

후처리

  1. concentrationThe mixture was concentrated
  2. customthe crude material used in the next step without further purification

출처 및 근거

ORD 기록
ord-377d50e1d6664017ba4a218ebd63499c
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093396B2

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