참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxybromide | HCID 24613 | — |
| 반응물 | Phosphorus tribromide | HCID 24614 | — |
| 반응물 | 5-Nitro-3-phenylpyridin-2-ol | HCID 178526835 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Bromo-5-nitro-3-phenylpyridine | HCID 86657253 | 62% |
반응 단계
A mixture of 5-nitro-3-phenylpyridin-2-ol (4.63 mmol, 1 g), POBr3 (4.74 mmol, 0.45 ml) and PBr3 (4.71 mmol, 1.4 g) was heated at 120° C. for 3.5 hours. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The organic phase was dried and evaporated affording 0.8 g (yield 62%) of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536165B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-da2a4b647a9443d59f2c8767e3498714 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
