5-Nitro-2,3-diphenylpyridine → 5,6-Diphenylpyridin-3-amine
반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][CH:9]=1)([O-])=O>CO.[Pd]>[C:16]1([C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[N:8][C:7]=2[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1참가 물질
4
실험 절차
A mixture of 5-nitro-2,3-diphenylpyridine (0.74 mmol, 0.21 g) and Pd/C 10% (0.02 g) in methanol (5 ml) was stirred for 16 hours under hydrogen atmosphere. The catalyst was filtered off and the solid thoughtfully washed with methanol. The solid residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 0.14 g (74% of yield) of the expected product.
후처리
- filtrationThe catalyst was filtered off
- washthe solid thoughtfully washed with methanol
- customThe solid residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate
- custommixtures affording
출처 및 근거
- ORD 기록
- ord-11f155da721a4d2686ce16e3395a406e
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08536165B2
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