2-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrile → 3-Amino-2-[(2-hydroxyethyl)amino]benzonitrile

HRID 419935노트

반응식

HRID 419935 반응식
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[C:12]([N+:13]([O-])=O)=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8].[H][H]>[Pd].CO>[NH2:13][C:12]1[C:5]([NH:4][CH2:3][CH2:2][OH:1])=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8]

참가 물질

5

반응물 2

HCID 114470952-[(2-Hydroxyethyl)amino]-3-nitrobenzonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 582984983-Amino-2-[(2-hydroxyethyl)amino]benzonitrile수율 106.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Methanol (500 ml) and Pd/activated charcoal 5% (wet, 3.45 g) are added to 2-[(2-hydroxyethyl)amino]-3-nitrobenzonitrile (69 g, 0.333 mol). The suspension is shaken in a Parr apparatus under 20 psi pressure of hydrogen for 1 hour. The mixture is then filtered on Celite and evaporated to dryness to give the desired material (62.7 g). This product is used in the next step without further purification.

후처리

  1. filtrationThe mixture is then filtered on Celite
  2. customevaporated to dryness

출처 및 근거

ORD 기록
ord-1e16d104712e47599c2f1eab463aeca0
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093402B2

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