참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxybromide | HCID 24613 | — |
| 반응물 | Phosphorus tribromide | HCID 24614 | — |
| 반응물 | HCID 178526832 | HCID 178526832 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,3-Dibromo-5-nitropyridine | HCID 1201425 | 73% |
반응 단계
A mixture of 3-bromo-5-nitropyridin-2-ol, POBr3 and PBr3 was heated at 120° C. for 3.5 h. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 2.63 g (yield 73%) of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536165B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-a4e2c39a7efe46fa98d2f35b3345c17e |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
