2-(3-Methoxyphenyl)-5-nitro-3-phenylpyridine → 6-(3-Methoxyphenyl)-5-phenylpyridin-3-amine

HRID 41997노트

반응식

HRID 41997 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:13][C:12]([N+:21]([O-])=O)=[CH:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[CH:11][C:12]([NH2:21])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 1

HCID 673943592-(3-Methoxyphenyl)-5-nitro-3-phenylpyridine

생성물 1

HCID 584158776-(3-Methoxyphenyl)-5-phenylpyridin-3-amine수율 69%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 2-(3-methoxyphenyl)-5-nitro-3-phenylpyridine (0.84 mmol, 0.257 g) and Pd/C 10% (0.08 mmol, 0.009 g) in ethanol (5 ml) was stirred for 16 hours under hydrogen atmosphere. The catalyst was filtered off and the solid thoughtfully washed with warm ethanol. The filtrate was evaporated and the crude was purified by chromatography over SiO2 eluting with DCM/methanol mixtures and affording 0.160 g (yield 69%) of the expected product.

후처리

  1. filtrationThe catalyst was filtered off
  2. washthe solid thoughtfully washed with warm ethanol
  3. customThe filtrate was evaporated
  4. customthe crude was purified by chromatography over SiO2 eluting with DCM/methanol mixtures

출처 및 근거

ORD 기록
ord-b6ed7be95b84411ca165bbe6e28bda04
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536165B2

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