Methylamine → ([2-(Methylamino)ethyl]sulfonyl)benzene
반응식
Cl[CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH3:13][NH2:14]>C(#N)C>[CH3:13][NH:14][CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5]참가 물질
4
실험 절차
A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.
후처리
- customThe solvent is removed in vacuo
- customthe residue is partitioned between methylene chloride and dilute sodium hydroxide
- extractionThe methylene chloride solution is extracted with dilute sulfuric acid
- extractionThe acidic extract
- extractionthe basic solution is extracted with methylene chloride
- dry with materialThe methylene chloride solution is dried over magnesium sulfate
- customthe solvent is removed in vacuo
출처 및 근거
- ORD 기록
- ord-ae4c77ae86b04fcaa9012d4cce7a5a3a
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04724235
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