Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 5-Bromo-2-(3-methoxyphenyl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2,5-Dibromopyridine | HCID 69353 | — |
| 반응물 | (3-Methoxyphenyl)boronic acid | HCID 2734370 | — |
| 용매 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | 2-Bromo-5-(3-methoxyphenyl)pyridine | HCID 15326155 | — |
| 생성물 | 5-Bromo-2-(3-methoxyphenyl)pyridine | HCID 49758519 | 43% |
반응 단계
In a schlenck tube, a mixture of 2,5-dibromopyridine (2.11 mmol, 0.500 g), 3-methoxyphenylboronic acid (2.11 mmol, 0.321 g), PdCl2dppf.DCM (0.21 mmol, 0.172 g), Cs2CO3 (6.33 mmol, 2.063 g) in a dioxane/water 4:1 mixture (14.5 ml) was heated at 100° C. for 14 hours, under argon atmosphere. The solvent was evaporated and the crude mixture was extracted between water and ethyl acetate. The solid residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 5-bromo-2-(3-methoxyphenyl)pyridine (0.242 g, yield 43%) as major product and 2-bromo-5-(3-methoxyphenyl)pyridine (0.039 g) as minor product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536165B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-3d31eae132414104885a110c6a7d5294 |
| 출처 메모 | uspto-grants-2013_09 |