HCID 178451554, 화합물 → HCID 178515376, 화합물

HRID 420151노트

반응식

HRID 420151 반응식
[O:1]=[C:2]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:24]3[NH:28][N:27]=[N:26][N:25]=3)[CH:22]=2)[O:17][C:4]2([CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2)[CH2:3]1>Cl.O1CCOCC1>[NH:28]1[C:24]([C:21]2[CH:22]=[C:23]3[C:18](=[CH:19][CH:20]=2)[O:17][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][C:2]3=[O:1])=[N:25][N:26]=[N:27]1

참가 물질

3

반응물 1

HCID 178451554HCID 178451554, 화합물

생성물 1

HCID 178515376HCID 178515376, 화합물

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

4 N HCl-1,4-dioxane (200 mL) was added to 40.6 g tert-butyl 4-oxo-6-(1H-tetrazol-5-yl)spiro[chroman-2,4′-piperidine]-1′-carboxylate produced in Reference Example 17, and stirred at room temperature for 5 hours. The reaction mixture was concentrated, and the residue was triturated with methanol. The insoluble solid was collected through filtration, and dried under reduced pressure to obtain 6-(1H-tetrazol-5-yl)-spiro[chroman-2,4′-piperidine]-4-one as a colorless solid.

후처리

  1. customproduced in Reference Example 17
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was triturated with methanol
  4. filtrationThe insoluble solid was collected through filtration
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-498688e63a1e444296f256c3e128be1b
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093389B2

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