2,5-Dibromopyridine → 5-Bromo-2-(5-ethoxy-2-fluorophenyl)pyridine

HRID 42018

반응식

HRID 42018 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[CH2:9]([O:11][C:12]1[CH:13]=[CH:14][C:15]([F:21])=[C:16](B(O)O)[CH:17]=1)[CH3:10]>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([C:14]2[CH:13]=[C:12]([O:11][CH2:9][CH3:10])[CH:17]=[CH:16][C:15]=2[F:21])=[N:3][CH:4]=1

참가 물질

3

반응물 2

HCID 693532,5-DibromopyridineHCID 162174685-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)

생성물 1

HCID 584158975-Bromo-2-(5-ethoxy-2-fluorophenyl)pyridine수율 47%

실험 절차

Obtained (1.18 g, yield 47%) following the procedure described in Intermediate 27, starting with 2,5-dibromopyridine (8.44 mmol, 2.0 g), 5-ethoxy-2-fluorophenylboronic acid (8.43 mmol, 1.55 g).

후처리

  1. customObtained (1.18 g, yield 47%)

출처 및 근거

ORD 기록
ord-3ccdc85e239b40e5a432e8c6cfb2af42
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536165B2

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