2,5-Dibromopyridine → 5-Bromo-2-(2-fluoro-5-isopropoxyphenyl)pyridine

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH:17]([CH3:19])[CH3:18])=[CH:12][C:11]=1B(O)O>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([C:15]2[CH:14]=[C:13]([O:16][CH:17]([CH3:18])[CH3:19])[CH:12]=[CH:11][C:10]=2[F:9])=[N:3][CH:4]=1

참가 물질

반응물 2

HCID 693532,5-Dibromopyridine

HCID 162176812-Fluoro-5-isopropoxyphenylboronic acid

생성물 1

HCID 584158265-Bromo-2-(2-fluoro-5-isopropoxyphenyl)pyridine수율 45%

실험 절차

Obtained (0.600 g, yield 45%) following the procedure described in Intermediate 27, starting with 2,5-dibromopyridine (4.22 mmol, 1.0 g), 2-fluoro-5-isopropoxyphenylboronic acid (4.22 mmol, 0.836 g).

후처리

customObtained (0.600 g, yield 45%)

출처 및 근거

ORD 기록: ord-bc0a9be7fff54887a162fd0e9355ce16
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536165B2

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