2,5-Dibromopyridine → 2-(5-Bromopyridin-2-yl)pyrazine

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.C([Sn](CCCC)(CCCC)[C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1)CCC>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([C:14]2[CH:19]=[N:18][CH:17]=[CH:16][N:15]=2)=[N:3][CH:4]=1

참가 물질

반응물 2

HCID 693532,5-Dibromopyridine

HCID 27373162-(Tributylstannyl)pyrazine

생성물 1

HCID 584157932-(5-Bromopyridin-2-yl)pyrazine수율 60%

실험 절차

Obtained (0.310 g, yield 60%) following the procedure described in Intermediate 37, starting with 2,5-dibromopyridine (2.11 mmol, 0.5 g), 2-(tributylstannyl)pyrazine (2.32 mmol, 0.857 g).

후처리

customObtained (0.310 g, yield 60%)

출처 및 근거

ORD 기록: ord-2e5cddc48e624af991d0c4d260bc7e29
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536165B2

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