3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → 3-Methyl-5-nitro-2-(3-(trifluoromethoxy)phenyl)pyridine

HRID 42025

반응식

HRID 42025 반응식
Br[C:2]1[C:7]([CH3:8])=[CH:6][C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[F:12][C:13]([F:25])([F:24])[O:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[CH3:8][C:7]1[C:2]([C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([O:14][C:13]([F:12])([F:24])[F:25])[CH:16]=2)=[N:3][CH:4]=[C:5]([N+:9]([O-:11])=[O:10])[CH:6]=1

참가 물질

3

반응물 2

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 52004662-Bromo-3-methyl-5-nitropyridine

생성물 1

HCID 673937803-Methyl-5-nitro-2-(3-(trifluoromethoxy)phenyl)pyridine수율 91%

실험 절차

Obtained (1.25 g, yield 91%) following the procedure described in Intermediate 27, starting with 2-bromo-3-methyl-5-nitropyridine (4.61 mmol, 1.0 g), 3-(trifluoromethoxy)phenyl boronic acid (4.61 mmol, 0.95 g).

후처리

  1. customObtained (1.25 g, yield 91%)

출처 및 근거

ORD 기록
ord-7da434c3faf646b18a54584636098cab
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536165B2

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