5-Amino-2-chloropyridine → 6-(2-Fluorophenyl)pyridin-3-amine

반응식

Cl[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1B(O)O>>[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 793055-Amino-2-chloropyridine

HCID 27343542-Fluorophenylboronic acid

생성물 1

HCID 189555756-(2-Fluorophenyl)pyridin-3-amine수율 31%

실험 절차

Obtained (0.210 g, yield 31%) following the procedure described in Intermediate 39, starting with 6-chloropyridin-3-amine (3.50 mmol, 0.45 g), 2-fluorophenylboronic acid (6.94 mmol, 0.97 g).

후처리

customObtained (0.210 g, yield 31%)

출처 및 근거

ORD 기록: ord-0c947ad444534faea050dadbc655e2c8
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536165B2

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