2-Bromobenzoic acid → 2-(6-Bromo-5-methylpyridin-3-ylamino)benzoic acid

반응식

[Br:1][C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[CH3:9].Br[C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>>[Br:1][C:2]1[N:7]=[CH:6][C:5]([NH:8][C:11]2[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])=[CH:4][C:3]=1[CH3:9]

참가 물질

반응물 2

HCID 69402-Bromobenzoic acid

HCID 123624465-Amino-2-bromo-3-methylpyridine

생성물 1

HCID 866572622-(6-Bromo-5-methylpyridin-3-ylamino)benzoic acid수율 14%

실험 절차

Obtained (0.17 g, yield 14%) following the procedure described in Intermediate 13 starting with 6-bromo-5-methylpyridin-3-amine (2.70 mmol, 0.5 g) and 2-bromobenzoic acid (4.03 mmol, 0.81 g).

후처리

customObtained (0.17 g, yield 14%)

출처 및 근거

ORD 기록: ord-e2d4ee53862b43bbbe2566f95278fedb
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536165B2

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