6-Bromopyridin-3-amine → 3',5'-Difluoro-2,4'-bipyridin-5-amine

반응식

Br[C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([F:29])[C:15]=1[Sn](CCCC)(CCCC)CCCC>>[F:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([F:29])[C:15]=1[C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[CH:6][N:7]=1

참가 물질

반응물 2

HCID 6428116-Bromopyridin-3-amine

HCID 164271233,5-Difluoro-4-(tributylstannyl)pyridine

생성물 1

HCID 584158393',5'-Difluoro-2,4'-bipyridin-5-amine수율 50%

실험 절차

Obtained (50% yield) following the procedure described in example 34 (step A), starting with 6-bromopyridin-3-amine and 3,5-difluoro-4-(tributylstannyl)pyridine.

후처리

customObtained (50% yield)

출처 및 근거

ORD 기록: ord-c4a5c136a52f45c5a1055d3fd4a0e082
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536165B2

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