[6-(2,4-Dichloro-phenyl)-imidazo[1,2-a]pyridin-7-ylmethyl]carbamic acid tert-butyl ester → C-[6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methylamine

HRID 420495노트

반응식

HRID 420495 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[C:14]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])=[CH:13][N:12]2[CH:23]=[CH:24][N:25]=[C:11]2[CH:10]=1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[Cl:22][C:16]1[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=1[C:14]1[C:9]([CH2:8][NH2:7])=[CH:10][C:11]2[N:12]([CH:23]=[CH:24][N:25]=2)[CH:13]=1

참가 물질

4

반응물 1

HCID 57906590[6-(2,4-Dichloro-phenyl)-imidazo[1,2-a]pyridin-7-ylmethyl]carbamic acid tert-butyl ester

생성물 1

HCID 24849505C-[6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methylamine수율 52.9%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of [6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-7-ylmethyl]-carbamic acid tert-butyl ester (30 mg, 0.07 mmol) in DCM (2 mL) and TFA (1 mL) was stirred at RT for 30 min, then concentrated to dryness. The remaining residue was purified by reverse phase prep-HPLC (Waters system) to give the title compound (2TFA salt, 19 mg, 0.037 mmol, 52%) as a white solid. MS: 293 [M+1]+; HPLC: AtRet=0.84.

후처리

  1. concentrationconcentrated to dryness
  2. customThe remaining residue was purified by reverse phase prep-HPLC (Waters system)

출처 및 근거

ORD 기록
ord-d0912f7be82747908f2991f8392641b0
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097617B2

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