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Sodium Carbonate → [3-Chloro-5-[2-[1-[5-(3-fluorophenyl)thiazole-2-yl]-4-pyrrolidine-1-ylpiperidine-4-yl]ethoxy]phenyl]acetic acid

HRID 420602
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HRID 420602 반응식
Br[C:2]1[S:6][C:5]([N:7]2[CH2:12][CH2:11][C:10]([CH2:18][CH2:19][O:20][C:21]3[CH:22]=[C:23]([CH2:28][C:29]([OH:31])=[O:30])[CH:24]=[C:25]([Cl:27])[CH:26]=3)([N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[CH2:9][CH2:8]2)=[N:4][CH:3]=1.[F:32][C:33]1[CH:34]=[C:35](B(O)O)[CH:36]=[CH:37][CH:38]=1.C(=O)([O-])[O-].[Na+].[Na+]>[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CN(C)C=O>[Cl:27][C:25]1[CH:24]=[C:23]([CH2:28][C:29]([OH:31])=[O:30])[CH:22]=[C:21]([O:20][CH2:19][CH2:18][C:10]2([N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[CH2:11][CH2:12][N:7]([C:5]3[S:6][C:2]([C:37]4[CH:36]=[CH:35][CH:34]=[C:33]([F:32])[CH:38]=4)=[CH:3][N:4]=3)[CH2:8][CH2:9]2)[CH:26]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 27339863-Fluorophenylboronic acidHCID 66657808[3-[2-[1-(5-Bromothiazole-2-yl)-4-pyrrolidine-1-ylpiperidine-4-yl]ethoxy]-5-chlorophenyl]acetic acid

생성물 1

HCID 57966811[3-Chloro-5-[2-[1-[5-(3-fluorophenyl)thiazole-2-yl]-4-pyrrolidine-1-ylpiperidine-4-yl]ethoxy]phenyl]acetic acid수율 24%

시약·촉매·용매 2

HCID 11979704
Tetrakis(triphenylphosphine)palladium
촉매
HCID 6228Dimethylformamide용매

실험 절차

A mixture of [3-[2-[1-(5-bromothiazole-2-yl)-4-pyrrolidine-1-ylpiperidine-4-yl]ethoxy]-5-chlorophenyl]acetic acid (60 mg), 3-fluorophenyl boronic acid (32 mg), tetrakis (triphenylphosphine) palladium (13 mg), 1M sodium carbonate (0.55 mL) and dimethylformamide (1 mL) was reacted with a microwave reaction device at 180° C. for 5 minutes. The insoluble material was filtrated. To the filtrate was added formic acid. The solvent was evaporated under reduced pressure and the residue was purified by high performance liquid chromatography to give the title compound (14.4 mg). Yield: 24%.

후처리

  1. customwas reacted with a microwave reaction device at 180° C. for 5 minutes
  2. filtrationThe insoluble material was filtrated
  3. additionTo the filtrate was added formic acid
  4. customThe solvent was evaporated under reduced pressure
  5. customthe residue was purified by high performance liquid chromatography

출처 및 근거

ORD 기록
ord-7f115ff0a20f484bb73ec10810e64a06
출처 데이터셋
uspto-grants-2012_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08097610B2

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