Water → 5-aminoisoquinolin-1(2H)-one

HRID 420616노트

반응식

HRID 420616 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][NH:8][C:9]2=[O:14])([O-])=O.[Cl-].[NH4+].O>C(O)C.O1CCCC1.[Zn]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][NH:8][C:9]2=[O:14]

참가 물질

7

반응물 3

HCID 962WaterHCID 25517Ammonium ChlorideHCID 2313785-Nitro-1,2-dihydroisoquinolin-1-one

생성물 1

HCID 20725-aminoisoquinolin-1(2H)-one수율 88.1%

시약·촉매·용매 3

HCID 23994Zinc촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

268.3 mg (1.51 mmol) of 5-nitroisoquinolin-1(2H)-one is added with 376.5 mg of ammonium chloride and 2.6 ml of water in 14 ml of ethanol and 5.4 ml of tetrahydrofuran. After addition in portions of 1.23 g of zinc powder (heating to 30 to 35° C.), it is stirred for two hours. The reaction mixture is suctioned off through a gas fiber filter and rewashed with ethyl acetate. After the filtrate is washed with water and saturated sodium chloride solution, the organic phase is dried as usual. Filtering off the desiccant and spinning off the solvent produce 196.5 mg (88.1%) of the desired amine.

후처리

  1. filtrationfilter
  2. washAfter the filtrate is washed with water and saturated sodium chloride solution
  3. customthe organic phase is dried as usual
  4. filtrationFiltering off the desiccant and

출처 및 근거

ORD 기록
ord-069d005dad6045d090b647034b3d2be8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097627B2

반응 노트

불러오는 중…