(6-Chloro-5-methylpyridin-3-yl)methanol → 6-Chloro-5-methylpyridine-3-carbaldehyde

HRID 420752

반응식

HRID 420752 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[CH3:10]>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[CH3:10]

참가 물질

3

반응물 1

HCID 11686949(6-Chloro-5-methylpyridin-3-yl)methanol

생성물 1

HCID 197106816-Chloro-5-methylpyridine-3-carbaldehyde수율 69.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

A mixture of (6-chloro-5-methyl-3-pyridinyl)methanol (300 mg, 1.904 mmol), CrO2 (Magtrieve) (2.398 g, 28.5 mmol), and DCM (15 ml) was stirred at 40° C. in a closed tube overnight. TLC showed some starting material remaining. Additional CrO2 (0.8 g) was added. After heating 4 additional hours, TLC showed full conversion. Filtration and concentration afforded 6-chloro-5-methyl-3-pyridinecarbaldehyde (204.8 mg, 69%) as a white solid.

후처리

  1. temperatureAfter heating 4 additional hours, TLC
  2. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-a96b34040b734cec8923f0d39fc8cb8d
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097628B2

연결된 노트

불러오는 중…