Sodium Bicarbonate → 6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline

HRID 420796노트

반응식

HRID 420796 반응식
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[Cl:13])[CH2:9][NH:8][CH2:7][CH2:6]2.C([O-])(O)=O.[Na+]>O.C(Cl)Cl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[Cl:13])[CH2:9][NH:8][CH2:7][CH2:6]2

참가 물질

5

반응물 2

HCID 516892Sodium BicarbonateHCID 125950786,7-Dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

생성물 1

HCID 125950776,7-Dichloro-1,2,3,4-tetrahydroisoquinoline수율 100.7%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

6,7-dichloro-1,2,3,4-tetrahydroisoquinoline HCl salt (550 mg, 2.31 mmol) was dissolved in water (5 mL) and DCM (20 mL). Aqueous saturated NaHCO3 (10 mL) was added and the organic phase was separated. The aqueous phase was extracted twice with DCM (20 mL), the organic phases were combined, dried (Na2SO4), and filtered to give 6,7-dichloro-1,2,3,4-tetrahydro-isoquinoline (470 mg, quant.).

후처리

  1. customthe organic phase was separated
  2. extractionThe aqueous phase was extracted twice with DCM (20 mL)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-2d46b5ffb69548b0a33cbe121da15847
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097636B2

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