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Potassium Carbonate → 2-Ethoxycarbonylmethyl-1-(4-isopropoxyphenyl)-5-(3-methoxycarbonyl-6-methyl-2-pyridinyloxy)indole-3-carboxylic acid ethyl ester

HRID 420938
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HRID 420938 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15]C3C=CC(C(F)(F)F)=CN=3)[CH:13]=2)[N:8]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH:33]([CH3:35])[CH3:34])=[CH:28][CH:27]=2)[C:7]=1[CH2:36][C:37]([OH:39])=[O:38])=[O:5])[CH3:2].C([O-])([O-])=O.[K+].[K+].[CH3:46][O:47][C:48](=[O:57])[C:49]1[CH:54]=[CH:53][C:52]([CH3:55])=[N:51][C:50]=1Cl.[CH2:58]1OCCOCCOCCOCCOCCO[CH2:59]1>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:50]3[C:49]([C:48]([O:47][CH3:46])=[O:57])=[CH:54][CH:53]=[C:52]([CH3:55])[N:51]=3)[CH:13]=2)[N:8]([C:26]2[CH:27]=[CH:28][C:29]([O:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:31]=2)[C:7]=1[CH2:36][C:37]([O:39][CH2:58][CH3:59])=[O:38])=[O:5])[CH3:2]
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참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 2855718-Crown-6HCID 13055804Methyl 2-chloro-6-methylpyridine-3-carboxylateHCID 666577852-Carboxymethyl-1-(4-isopropoxyphenyl)-5-(5-trifluoromethyl-2-pyridinyloxy)indole-3-carboxylic acid ethyl ester

생성물 1

HCID 666577182-Ethoxycarbonylmethyl-1-(4-isopropoxyphenyl)-5-(3-methoxycarbonyl-6-methyl-2-pyridinyloxy)indole-3-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
90 °C

실험 절차

The sub-title compound was prepared in accordance with step (a) Example 24 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-isopropoxyphenyl)-indole-3-carboxylic acid ethyl ester (250 mg, 0.59 mmol, see (b) Example 12), K2CO3 (244 mg, 1.77 mmol), 2-chloro-6-methylnicotinic acid methyl ester (163 mg, 0.88 mmol), 18-crown-6 (16 mg, 0.06 mmol) and DMF (2 mL). The reaction mixture was heated at 90° C. for 4 d and worked-up as described before. Yield 80 mg (32%).

출처 및 근거

ORD 기록
ord-71b81d1032d541709a26afaf3e7cfa9a
출처 데이터셋
uspto-grants-2012_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08097623B2

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