5-Methylsalicylic acid → N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-hydroxy-5-methylbenzamide

반응식

[CH3:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][C:14]=1[C:20]([F:23])([F:22])[F:21]>>[Cl:12][C:13]1[CH:19]=[CH:18][C:16]([NH:17][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=2[OH:11])=[CH:15][C:14]=1[C:20]([F:21])([F:22])[F:23]

참가 물질

반응물 2

HCID 69735-Methylsalicylic acid

HCID 675744-Chloro-3-(trifluoromethyl)aniline

생성물 1

HCID 66657203N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-hydroxy-5-methylbenzamide수율 70.4%

실험 절차

Using 5-methylsalicylic acid and 4-chloro-3-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

출처 및 근거

ORD 기록: ord-b1309ccdf9764d2bb8398aba0ca76fdb
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08097759B2

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