5-Bromosalicylic acid → 5-Bromo-N-(5-methyl-4-phenylthiazol-2-yl)-2-hydroxybenzamide

반응식

[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([CH3:24])=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][C:15]([CH3:24])=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)=[O:9]

참가 물질

반응물 2

HCID 69725-Bromosalicylic acid

HCID 961292-Amino-4-phenyl-5-methylthiazole

생성물 1

HCID 178601415-Bromo-N-(5-methyl-4-phenylthiazol-2-yl)-2-hydroxybenzamide

실험 절차

Using 5-bromosalicylic acid and 2-amino-5-methyl-4-phenylthiazole as the raw materials, the same operation as the example 16 gave the title compound. (2-Amino-5-methyl-4-phenylthiazole: refer to Yakugaku Zasshi, 1961, 81, 1456.)

출처 및 근거

ORD 기록: ord-a294d599f086460db81e2d9702f330f9
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08097759B2

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