5-Chlorosalicylic Acid → 2-(5-Chloro-2-hydroxybenzoyl)amino-4-phenylthiazole-5-carboxylic acid ethyl ester

HRID 421171

반응식

HRID 421171 반응식
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[CH2:12]([O:14][C:15]([C:17]1[S:21][C:20]([NH2:22])=[N:19][C:18]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[S:21][C:20]([NH:22][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[OH:11])=[N:19][C:18]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:16])[CH3:13]

참가 물질

3

반응물 2

HCID 94475-Chlorosalicylic AcidHCID 73239Ethyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate

생성물 1

HCID 865955422-(5-Chloro-2-hydroxybenzoyl)amino-4-phenylthiazole-5-carboxylic acid ethyl ester수율 69.4%

실험 절차

Using 5-chlorosalicylic acid and 2-amino-4-phenylthiazole-5-carboxylic acid ethyl ester as the raw materials, the same operation as the example 195(3) gave the title compound.

출처 및 근거

ORD 기록
ord-d263fa48cb844857b41726aea2ea56ff
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097759B2

연결된 노트

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