2-Amino-6-nitrobenzothiazole → 2,6-Benzothiazolediamine

HRID 421291

반응식

HRID 421291 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:5]=2[N:6]=1.[H][H]>CO.[Pd]>[S:3]1[C:4]2[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[NH2:1]

참가 물질

5

반응물 2

HCID 227042-Amino-6-nitrobenzothiazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 215042,6-Benzothiazolediamine수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-Amino-6-nitrobenzothiazole (1.0 g, 5.12 mmol) was dissolved in 100 ml of MeOH and palladium on activated carbon (10%, 545 mg, 0.51 mmol) was added. The reaction mixture was hydrogenated using hydrogen at RT (3 bar H2) for 2.5 h. The mixture was filtered, the solvent was removed under reduced pressure and the residue was purified using silica gel chromatography (ethyl acetate:n-heptane 1:2). 0.81 g (yield: 96%) of the purified title compound was obtained.

후처리

  1. customat RT
  2. customfor 2.5 h
  3. filtrationThe mixture was filtered
  4. customthe solvent was removed under reduced pressure
  5. customthe residue was purified
  6. custom0.81 g (yield: 96%) of the purified title compound
  7. customwas obtained

출처 및 근거

ORD 기록
ord-33d67ecb6f9447b3a700208fec01f7c7
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097758B2

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