Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → Tert-butyl[4-((2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionylamino)benzyl]-carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | HOAt | HCID 181649 | — |
| 반응물 | PyBroP | HCID 2733179 | — |
| 반응물 | tert-butyl N-[(4-aminophenyl)methyl]carbamate | HCID 2756041 | — |
| 반응물 | N-Benzoyl-3-phenylisoserine, (2R,3S)- | HCID 2762289 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Tert-butyl[4-((2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionylamino)benzyl]-carbamate | HCID 24798298 | — |
반응 단계
Analogously to Example 1, Process step 1, 33 mg (0.15 mmol) of tert-butyl (4-aminobenzyl)carbamate and 43 mg (0.15 mmol) of (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionic acid were dissolved in 1 ml of DCM and 1 ml of DMF and treated successively with 78 μl of DIPEA (0.45 mmol), 22.5 mg of HOAt (0.165 mmol) and 76.9 mg (0.165 mmol) of PyBrop. Without further work-up, the batch obtained was filtered and then purified using HPLC. The product-containing fractions were lyophilized.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08097758B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-cd6d0b9e14c84780b236df41a3438fee |
| 출처 메모 | uspto-grants-2012_01 |