1-Bromo-2-methylpropane → 2-Chloro-9-isobutyl-6-morpholin-4-yl-9H-purine

HRID 421295노트

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HRID 421295 반응식
[CH2:1](Br)[CH:2]([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+].[Cl:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[CH:18][NH:19]2)=[C:15]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[N:14]=1>CN(C)C=O>[Cl:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[CH:18][N:19]2[CH2:1][CH:2]([CH3:4])[CH3:3])=[C:15]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[N:14]=1

참가 물질

5

반응물 3

HCID 65551-Bromo-2-methylpropaneHCID 11430Potassium CarbonateHCID 32746034-(2-chloro-9H-purin-6-yl)morpholine

생성물 1

HCID 580152192-Chloro-9-isobutyl-6-morpholin-4-yl-9H-purine수율 103.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
80 °C

실험 절차

N,N-Dimethylformamide (60 ml), isobutyl bromide (2 ml, 18 mmol), and potassium carbonate (3 g) were added to 2-chloro-6-morpholin-4-yl-9H-purine (5 g, 17 mmol) and the resulting mixture was stirred at 80° C. for 5 hours. The reaction mixture was cooled and partitioned with ethyl acetate and water and the organic layer was dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (5.2 g, 100%) as a pale yellow oil.

후처리

  1. temperatureThe reaction mixture was cooled
  2. custompartitioned with ethyl acetate and water
  3. dry with materialthe organic layer was dried over magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-0dd0b59b1f2849539f64b92642666dc4
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097622B2

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