참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | 2-Methylpiperazine, (S)- | HCID 2734219 | — |
| 반응물 | 5-(8-Chloro-9-isobutyl-6-morpholino-9H-purin-2-yl)pyrimidin-2-amine | HCID 59333549 | — |
| 생성물 | Formate | HCID 283 | — |
| 생성물 | 5-{9-Isobutyl-8-[(3S)-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9H-purin-2-yl}pyrimidin-2-amine | HCID 59333517 | — |
반응 단계
N-Methylpyrrolidone (2 ml) was added to 5-(8-chloro-9-isobutyl-6-morpholin-4-yl-9H-purin-2-yl)pyrimidin-2-amine (200 mg, 0.51 mmol) and (2S)-2-methylpiperazine (412 mg, 4.1 mmol) and the resulting mixture was stirred at 120° C. for 4 hours. The reaction mixture was purified by preparative HPLC (column, NOMURA Develosil Combi-RP-5; mobile phase, acetonitrile/water/formic acid) to give a formate of the title compound (192 mg) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08097622B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-c91aeb8fb32340fd827ace7a10f56977 |
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| 출처 메모 | uspto-grants-2012_01 |
|---|
