Sulfuric Acid → HCID 86647093, 화합물

HRID 421565

반응식

HRID 421565 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[S:28](=[O:32])(=[O:31])([OH:30])[OH:29]>C(O)(C)C>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[S:28]([O-:32])([O-:31])(=[O:30])=[O:29]

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 5002Quetiapine

생성물 1

HCID 86647093HCID 86647093, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
27.5 °C

실험 절차

Quetiapine free base (5.0 g) was dissolved in isopropyl alcohol (50 ml) at room temperature. This was followed by addition of 98% sulfuric acid (1.28 g) at 30 to 35° C. The resulting gummy mass was heated to reflux and maintained for 15 minutes. The resulting mass was cooled at 25-30° C. and stirred for 1 hour. The precipitated product was collected by filtration, washed with isopropyl alcohol (25 ml) and dried to give the title compound as off white powder (5.88 g).

후처리

  1. temperatureThe resulting gummy mass was heated
  2. temperatureto reflux
  3. temperaturemaintained for 15 minutes
  4. filtrationThe precipitated product was collected by filtration
  5. washwashed with isopropyl alcohol (25 ml)
  6. customdried

출처 및 근거

ORD 기록
ord-4d4e834c097e48cd99a19b42b4acf138
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101597B2

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