Nitric Acid → Quetiapine Nitrate

HRID 421567

반응식

HRID 421567 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[N+:28]([O-:31])([OH:30])=[O:29]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[N+:28]([O-:31])([O-:30])=[O:29]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 5002Quetiapine

생성물 1

HCID 86647094Quetiapine Nitrate수율 80.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of 68 to 72% nitric acid (0.7 g) at 20 to 25° C. The resulting precipitated solid was stirred for 1 hour. The precipitated product was collected by filtration, washed with acetone (15 ml) and dried to give the title compound as white powder (4.0 g).

후처리

  1. customThe resulting precipitated solid
  2. filtrationThe precipitated product was collected by filtration
  3. washwashed with acetone (15 ml)
  4. customdried

출처 및 근거

ORD 기록
ord-bf4fd07b135d4045b967766573be7751
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101597B2

연결된 노트

불러오는 중…