Citric Acid → Quetiapine Citrate

HRID 421569

반응식

HRID 421569 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]([OH:40])(=[O:39])[CH2:29][C:30]([CH2:35][C:36]([OH:38])=[O:37])([C:32]([OH:34])=[O:33])[OH:31]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]([O-:40])(=[O:39])[CH2:29][C:30]([CH2:35][C:36]([O-:38])=[O:37])([C:32]([O-:34])=[O:33])[OH:31]

참가 물질

4

반응물 2

HCID 311Citric AcidHCID 5002Quetiapine

생성물 1

HCID 86647095Quetiapine Citrate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of citric acid (1.1 g) at 30 to 35° C. The resulting mass was heated at reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.95 g).

후처리

  1. temperatureThe resulting mass was heated
  2. temperatureat reflux
  3. temperaturemaintained for 30 minutes
  4. distillationThis was followed by the distillation of acetone
  5. customobtained solid
  6. customwas further dried under vacuum

출처 및 근거

ORD 기록
ord-4a3066286e1c48888a8b6017ba2bc218
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101597B2

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