Quetiapine → HCID 131729402, 화합물

HRID 421570

반응식

HRID 421570 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([OH:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:49]=[CH:48][C:47]([CH3:50])=[CH:46][CH:45]=2)=[O:43])([OH:41])[C:38]([OH:40])=[O:39])=[O:35])=[CH:30][CH:29]=1>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([O-:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:45]=[CH:46][C:47]([CH3:50])=[CH:48][CH:49]=2)=[O:43])([OH:41])[C:38]([O-:40])=[O:39])=[O:35])=[CH:30][CH:29]=1

참가 물질

4

반응물 2

HCID 5002QuetiapineHCID 29414711Di-para-toluoyl-L-tartaric acid

생성물 1

HCID 131729402HCID 131729402, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Quetiapine free base (3.0 g) was dissolved in acetone (30 ml) at room temperature. To this solution was added di-p-toluoyl-L-tartaric acid (1.52 g) at 30 to 35° C. The resulting mass heated to reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.62 g).

후처리

  1. temperatureThe resulting mass heated
  2. temperatureto reflux
  3. temperaturemaintained for 30 minutes
  4. distillationThis was followed by the distillation of acetone
  5. customobtained solid
  6. customwas further dried under vacuum

출처 및 근거

ORD 기록
ord-06dbf6660c6847878637dcbfbbfbcc4f
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101597B2

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