Acetyl chloride → HCID 178496609, 화합물

HRID 421622노트

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HRID 421622 반응식
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][CH3:16])[CH2:11][CH2:10]1)=O)(C)(C)C.C(Cl)(=O)C>C(O)C>[CH3:16][O:15][C@H:12]1[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]1

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 178496620HCID 178496620, 화합물

생성물 1

HCID 178496609HCID 178496609, 화합물수율 126.6%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
0 °C

실험 절차

trans-(tert-Butoxy)-N-(4-methoxycyclohexyl)carboxamide (642 mg, 2.80 mmol) was dissolved in ethanol (5 mL) and cooled to 0° C. Acetyl chloride (1.5 mL) was added and the reaction was allowed to reach room temperature and stirred overnight. Solvent was removed in vacuo to give the desired product (458 mg, quantitative yield) as a hydrochloride salt. ES-MS: 130 (M+1).

후처리

  1. customto reach room temperature
  2. customSolvent was removed in vacuo

출처 및 근거

ORD 기록
ord-2784ce9424ef45bfacdb67e0e0e9046d
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101588B2

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