(R)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol → (r)-Tert-butyl 1-(2-amino-3-carbamoyl-9h-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate

HRID 421658

반응식

HRID 421658 반응식
[NH2:1][C:2]1[C:3]([C:27]([NH2:29])=[O:28])=[CH:4][C:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([CH2:14][C:15]3([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:17]C3)[C:6]=2[N:26]=1.[CH2:30]([O:37]C[C@H](NC(=O)OC(C)(C)C)CI)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C(OC(=O)N[C@@H](C)CI)(C)(C)C.N(C(OC(C)(C)C)=O)[C@H](CO)COCC1C=CC=CC=1.C(OC(=O)NC1(CI)CC1)(C)(C)C>>[NH2:1][C:2]1[C:3]([C:27](=[O:28])[NH2:29])=[CH:4][C:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([CH2:14][C@@H:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:17][O:37][CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:6]=2[N:26]=1

참가 물질

6

반응물 5

HCID 11065873(R)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanolHCID 15529790HCID 15529790, 화합물HCID 24901061HCID 24901061, 화합물HCID 66675623HCID 66675623, 화합물HCID 86648312HCID 86648312, 화합물

생성물 1

HCID 59613115(r)-Tert-butyl 1-(2-amino-3-carbamoyl-9h-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate

실험 절차

(R)-tert-butyl 1-(2-amino-3-carbamoyl-9H-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate (xvi-d) was prepared following the procedure detailed in the preparation of 63, substituting (S)-tert-butyl 1-(benzyloxy)-3-iodopropan-2-ylcarbamate (prepared as detailed in the synthesis of xxvii from commercial N-Boc-L-Ser(Bzl)-ol) for tert-butyl[1-(iodomethyl)cyclopropyl]carbamate. NH4OAc QC conditions. M+H=490.

후처리

  1. customprepared

출처 및 근거

ORD 기록
ord-a575ba8bd3ae445683a3b71fc90484e0
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101604B2

연결된 노트

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