2-Chloro-4-(methylsulfonyl)benzoic acid → Nicotinamide

HRID 421698

반응식

HRID 421698 반응식
NC1C=CC(Cl)=C([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[N:12][CH:11]=2)C=1.ClC1C=C(S(C)(=O)=O)C=CC=1C(O)=O>>[C:9]([NH2:8])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[N:12][CH:11]=1

참가 물질

3

반응물 2

HCID 7358632-Chloro-4-(methylsulfonyl)benzoic acidHCID 28867202N-(5-Amino-2-chlorophenyl)nicotinamide

생성물 1

HCID 936Nicotinamide

실험 절차

N-(5-amino-2-chlorophenyl)nicotinamide (0.40 mmol) was used in general procedure 2 with 2-chloro-4-(methylsulfonyl)benzoic acid (0.48 mmol). The product was purified by RP-HPLC to give N-(2-chloro-4-(methylsulfonyl)benzamido)phenyl)nicotinamide. MS (Q1) 464.0 (M)+

후처리

  1. customThe product was purified by RP-HPLC

출처 및 근거

ORD 기록
ord-1e1bd51e940d40f0a15ca1091c84de62
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101610B2

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