1-Acetylpiperazine → Nicotinamide

HRID 421711노트

반응식

HRID 421711 반응식
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC=C(Cl)C=3)C=2)=[O:7])=[CH:4][N:3]=1.C(N1CCNCC1)(=O)C>>[C:6]([NH2:8])(=[O:7])[C:5]1[CH:26]=[CH:27][CH:2]=[N:3][CH:4]=1

참가 물질

3

반응물 2

HCID 837951-AcetylpiperazineHCID 167312706-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide

생성물 1

HCID 936Nicotinamide

실험 절차

6-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide (0.16 mmol) was used in general procedure 3 with 1-acetylpiperazine (0.83 mmol). The product was purified by RP-HPLC to give 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-(3-chlorobenzamido)phenyl))phenyl)nicotinamide. MS (Q1) 512.0 (M)+

후처리

  1. customThe product was purified by RP-HPLC

출처 및 근거

ORD 기록
ord-11a0eef36e0941eeb19449e8902f171e
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101610B2

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