(3-Trifluoromethylphenyl)urea → HCID 59684832, 화합물

HRID 421808노트

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HRID 421808 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH2:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[C:15]([C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1)#[N:16].[Br:25][C:26]1[CH:31]=[CH:30][C:29]([C:32](=[O:37])[CH2:33][C:34](=O)[CH3:35])=[CH:28][CH:27]=1>O1CCCC1>[Br:25][C:26]1[CH:27]=[CH:28][C:29]([C:32]([C:33]2[CH:21]([C:20]3[CH:23]=[CH:24][C:17]([C:15]#[N:16])=[CH:18][CH:19]=3)[NH:12][C:10](=[O:11])[N:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:13])([F:14])[F:1])[CH:4]=3)[C:34]=2[CH3:35])=[O:37])=[CH:30][CH:31]=1

참가 물질

5

반응물 3

HCID 25712(3-Trifluoromethylphenyl)ureaHCID 660424-CyanobenzaldehydeHCID 4326531-(4-bromophenyl)butane-1,3-dione

생성물 1

HCID 59684832HCID 59684832, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4.23 g (20.74 mmol) N-[3-(trifluoromethyl)phenyl]urea, 2.72 g (20.74 mmol) 4-cyanobenzaldehyde, 5.00 g (20.74 mmol) 1-(4-bromophenyl)butane-1,3-dione and 6.5 g polyphosphoric acid ethyl ester are suspended in 50 ml of tetrahydrofuran. The mixture is stirred at reflux for 20 hours. After cooling down to room temperature, the solvent is removed in vacuo and the residue is purified by column chromatography on silica with cyclohexane/ethyl acetate mixtures as eluent.

후처리

  1. temperatureat reflux for 20 hours
  2. customthe solvent is removed in vacuo
  3. customthe residue is purified by column chromatography on silica with cyclohexane/ethyl acetate

출처 및 근거

ORD 기록
ord-b6ef96fb8dfa4df8b48d39d5d0ee7d67
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101615B2

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